![]() ![]() Catecholamines stimulate lipolysis through activating β-adrenergic receptors in target tissues, predominantly adipose tissue and muscle ( 11). Under fasting conditions or high energy needs, the stored TAG in adipocytes is hydrolyzed into free fatty acids (FFAs) and glycerol via activation of lipolytic pathways ( 10). During periods of excessive caloric intake, almost excess energy is stored as triacylglycerol (TAG) in lipid droplets during lipogenesis. Experimental studies also showed that acupuncture treatment effectively decreased BW of high-fat diet (HFD)-induced obese rats or mice by affecting the satiety center ( 8), the neuroendocrine system ( 4), and regulating inflammatory responses ( 9), although the underlying mechanism is not yet entirely clear.įat is the largest energy reserve in mammals. In addition to reducing body weight (BW), body mass index, and waist-to-hip ratio effectively, there is a growing body of evidence showing that acupuncture improved obesity-associated dyslipidemia, leptin concentration, and inflammation, suggesting that acupuncture is as effective for obese individuals ( 4– 7). Acupuncture for treatment of obesity in China for centuries is the most rapidly growing complementary and alternative therapy that is recognized by both the NIH and the WHO. ![]() Obesity and overweight are closely related to cardiovascular disease, type 2 diabetes mellitus, hypertension, and cancer, which have severely threatened human health and life and attracted much attention in many countries ( 1– 3). This ameliorative effect of EA on obesity-related symptoms associated with its promoted adipose tissue plasticity via activating sympathetic nerves. Meanwhile, EA promoted the protein and mRNA expressions of UCP1, PRDM16, and PGC-1α in adipose tissue, and activated sympathetic nerves via p-TH, A2AR, and β3AR in white adipose tissue.Ĭonclusions: EA reduced food intake, BW, TG, and cholesterol, and improved glucose tolerance in HFD mice. Compared with the CD mice, the HFD mice had elevated fasting serum glucose level and impaired glucose tolerance however, these parameters were decreased by EA treatment. Results: EA significantly reduced food intake, BW, and white adipose tissue (WAT)/BW ratio decreased the adipocyte size and serum concentrations of triglyceride (TG) and cholesterol and increased oxygen consumption in HFD mice. Blood samples and adipose tissue were collected for the analysis of leptin, triglyceride levels, and fat browning-related proteins. ![]() Intraperitoneal glucose tolerance test and metabolic chamber recordings were performed. ![]() After 12 weeks, CD and HFD mice were randomly divided into two groups, respectively, to receive or not receive EA for 4 weeks. Methods: Three-week-old male C56BL/6 mice were randomly divided to feed or not to feed high-fat diet (HFD), named HFD group and chow diet (CD) group, respectively. Objective: This study investigated the influence of electroacupuncture (EA) and its potential underlying mechanisms on adipose tissue in obese mice. 3Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, China.2Huai’an Hospital of Traditional Chinese Medicine, Huaian, China.1Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, China.With Da Zao, harmonizes and protects the Spleen and Stomach.Sheng-Feng Lu 1†, Yue-Xia Tang 1,2†, Tao Zhang 1, Shu-Ping Fu 1, Hao Hong 1, Yu Cheng 1, Hou-Xi Xu 1, Xing-Yue Jing 1, Mei-Ling Yu 1* and Bing-Mei Zhu 3* With Chai Hu and Huang Qi, raises Sunken Yang. Raises Yang, raises sunken Qi and guides other herbs upwards. Regulates Qi, tonifies the Spleen, assists raising Qi, aids digestion of tonics and prevents bloating which may accompany Qi tonics. With Huang Qi, Ren Shen, Bai Zhu and Zhi Gan Cao, augments Qi by Invigorating Blood. Tonifies the Qi of the Blood and invigorates and harmonizes the Blood. Strengthens the Spleen and dries Dampness. With Bai Zhu and Zhi Gan Cao, assists Huang Qi in strengthening Qi. Strongly tonifies Qi, reinforces Yang and harmonizes the Middle Jiao. With Bai Zhu, for Spleen Qi Deficiency with weakness, lassitude and loose stools. With Ren Shen, for Qi Deficiency with general debility, anorexia and spontaneous perspiration. Strongly tonifies Qi, strengthens the Spleen and raises Spleen Yang. ![]()
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